{"id":159530,"date":"2022-05-23T11:31:03","date_gmt":"2022-05-23T21:31:03","guid":{"rendered":"https:\/\/www.hawaii.edu\/news\/?p=159530"},"modified":"2022-05-25T10:19:04","modified_gmt":"2022-05-25T20:19:04","slug":"cumulina-named-national-treasure","status":"publish","type":"post","link":"https:\/\/www.hawaii.edu\/news\/2022\/05\/23\/cumulina-named-national-treasure\/","title":{"rendered":"<abbr>糖心Vlog官方<\/abbr> scientific relic deemed &lsquo;National Treasure,&rsquo; makes new home at Smithsonian museum"},"content":{"rendered":"<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Reading time: <\/span> <span class=\"rt-time\"> 3<\/span> <span class=\"rt-label rt-postfix\">minutes<\/span><\/span><div class=\"responsive-video-wrap-post\"><figure class=\"wp-block-embed wp-block-embed-youtube is-type-video is-provider-youtube epyt-figure\"><div class=\"wp-block-embed__wrapper\"><div class=\"epyt-video-wrapper\"><iframe  id=\"_ytid_37514\"  width=\"676\" height=\"676\"  data-origwidth=\"676\" data-origheight=\"676\" src=\"https:\/\/www.youtube.com\/embed\/p3KVheTycgA?enablejsapi=1&origin=https:\/\/www.hawaii.edu&rel=0&autoplay=0&cc_load_policy=0&cc_lang_pref=&iv_load_policy=1&loop=0&fs=1&playsinline=0&autohide=2&theme=dark&color=red&controls=1&disablekb=0&\" class=\"__youtube_prefs__  no-lazyload\" title=\"糖心Vlog官方 scientific relic deemed \u2018National Treasure,\u2019 makes new home at Smithsonian museum\"  allow=\"fullscreen; accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen data-no-lazy=\"1\" data-skipgform_ajax_framebjll=\"\"><\/iframe><\/div><\/div><\/figure><\/div>\n<p>Nearly 25 years after her birth made international headlines, Cumulina, the first cloned mouse and the first cloned mammal in the United States recently made the trek to her new home in the renowned Smithsonian\u2019s <a href=\"https:\/\/americanhistory.si.edu\/\">National Museum of American History<\/a> in Washington, <abbr>D.C.<\/abbr> <\/p>\n<figure id=\"attachment_159543\" aria-describedby=\"caption-attachment-159543\" style=\"width: 250px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2022\/05\/manoa-jabsom-cumulina-display-smithsonian.jpeg\" alt=\"mouse on display\" width=\"250\" height=\"350\" class=\"size-full wp-image-159543\" srcset=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2022\/05\/manoa-jabsom-cumulina-display-smithsonian.jpeg 250w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2022\/05\/manoa-jabsom-cumulina-display-smithsonian-214x300.jpeg 214w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2022\/05\/manoa-jabsom-cumulina-display-smithsonian-93x130.jpeg 93w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><figcaption id=\"caption-attachment-159543\" class=\"wp-caption-text\">Photo credit: Richard Strauss, Smithsonian National Museum of American History<\/figcaption><\/figure>\n<p>The most celebrated mouse in scientific history was named for the cumulus cells whose nuclei were used to clone her. Cumulina was created in a lab in 1997 using the distinctive &ldquo;Honolulu Technique&rdquo; developed by an international team led by <strong><a href=\"https:\/\/www.hawaii.edu\/news\/2018\/08\/28\/yanagimachi-inaugural-symposium\/\">Ryuzo Yanagimachi<\/a><\/strong> at the <abbr title=\"University of Hawaii\">糖心Vlog官方<\/abbr> M\u0101noa <a href=\"http:\/\/jabsom.hawaii.edu\">John A. Burns School of Medicine<\/a>. Yanagimachi\u2019s work helped lay the groundwork for in vitro fertilization in the early 1960s. Although Yanagimachi officially retired in 2005, he continues to be an active researcher at <abbr>糖心Vlog官方<\/abbr> M\u0101noa <a href=\"https:\/\/www.ibr.hawaii.edu\/\">Institute for Biogenesis Research<\/a> (<abbr>IBR<\/abbr>), which he founded.<\/p>\n<p>&ldquo;I view Cumulina as being an ambassador to the world for the biomedical research that\u2019s done at the University of <span aria-label=\"Hawaii\">Hawai&#699;i<\/span>. The University of <span aria-label=\"Hawaii\">Hawai&#699;i<\/span> is a world-class Research 1 university. The discovery that a mouse could be cloned over and over again happened here before it happened anywhere else in the world,&rdquo; said <strong>W. Steven Ward<\/strong>, director of the <abbr>IBR<\/abbr> and <abbr>JABSOM<\/abbr> professor.<\/p>\n<p>Cumulina lived to a ripe age of 31 months, equivalent to age 95 in human years. She died of natural causes in 2001 and until she was donated to the museum, had been kept at the <abbr>糖心Vlog官方<\/abbr> <abbr>IBR<\/abbr>, part of <abbr>JABSOM<\/abbr>.<\/p>\n<figure id=\"attachment_159544\" aria-describedby=\"caption-attachment-159544\" style=\"width: 300px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2022\/05\/manoa-jabsom-ibr-yanagimachi-300x169.jpeg\" alt=\"Ryuzo Yanagimachi\" width=\"300\" height=\"169\" class=\"size-medium wp-image-159544\" srcset=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2022\/05\/manoa-jabsom-ibr-yanagimachi-300x169.jpeg 300w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2022\/05\/manoa-jabsom-ibr-yanagimachi-130x73.jpeg 130w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2022\/05\/manoa-jabsom-ibr-yanagimachi.jpeg 676w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-159544\" class=\"wp-caption-text\">Ryuzo Yanagimachi looks on as teams pack Cumulina for the Smithsonian.<\/figcaption><\/figure>\n<p>&ldquo;The fact that the Smithsonian Institute so eagerly accepted this gift is confirmation of the place in history that the discovery has. We are thrilled that the University of <span aria-label=\"Hawaii\">Hawai&#699;i<\/span> will now be recognized in the nation\u2019s flagship history museum as having made a major discovery in biomedical science,&rdquo; said Ward.<\/p>\n<p>Along with Cumulina, the museum also acquired a sheet of paper streaked with the mouse\u2019s footprints, made on her second birthday, which speaks to the research team\u2019s excitement about the mouse\u2019s normal aging process.<\/p>\n<p>&ldquo;Cumulina is a wonderful addition to our collection,&rdquo; said Curator Kristen Frederick-Frost. &ldquo;This tiny mouse will help our audiences explore complex topics, from the science of making copies of organisms to the ethics of doing so. When Cumulina was born, people wondered what, or who, was next. We still wonder. She is a part of the past that pushes us to consider the possibilities of the future.&rdquo;<\/p>\n<h2><em>Smithsonian<\/em> magazine spotlight<\/h2>\n<figure id=\"attachment_159547\" aria-describedby=\"caption-attachment-159547\" style=\"width: 250px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2022\/05\/manoa-jabsom-cumulina.jpeg\" alt=\"cumulina on display\" width=\"250\" height=\"350\" class=\"size-full wp-image-159547\" srcset=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2022\/05\/manoa-jabsom-cumulina.jpeg 250w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2022\/05\/manoa-jabsom-cumulina-214x300.jpeg 214w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2022\/05\/manoa-jabsom-cumulina-93x130.jpeg 93w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><figcaption id=\"caption-attachment-159547\" class=\"wp-caption-text\">Cumulina before being carefully packed for shipping to the Smithsonian Museum.<\/figcaption><\/figure>\n<p>Like a celebrity, Cumulina was greeted in her new hometown with a special photoshoot courtesy of <a href=\"https:\/\/www.smithsonianmag.com\"><em>Smithsonian<\/em> magazine<\/a>. She\u2019ll be featured in the <a href=\"https:\/\/www.smithsonianmag.com\/smithsonian-institution\/mouse-squeak-history-science-180980041\/\">National Treasure column in the June 2022 issue of <em>Smithsonian<\/em> Magazine<\/a>. In <abbr>D.C.<\/abbr>, she will be preserved in the museum\u2019s Medicine and Science Division. <\/p>\n<p>&ldquo;I\u2019m happy that more people can see her than here at <abbr>IBR<\/abbr>\u2026 It&#8217;s very good for us and for Cumulina too,&rdquo; said Yanagimachi.<\/p>\n<p>While the museum is exploring future display opportunities, details about Cumulina will be available on the museum\u2019s website and in the American Treasures column of the <em>Smithsonian<\/em> Magazine. Cumulina was the first mammal to be cloned more than once and for several generations. In fact, the Yanagimachi Laboratory produced more than 50 carbon-copy mice using what was thought to be a more reliable cloning technique than the one used to create Dolly the Sheep. The clear reproducibility of the Honolulu Technique for cloning mammals convinced the world that cloning was real. <\/p>\n<p><a href=\"https:\/\/www.flickr.com\/photos\/uhmed\/sets\/72157719793382648\/\">View photos of Cumulina on her way to Washington, D.C.<\/a><\/p>\n<p>This work is an example of <abbr>糖心Vlog官方<\/abbr> M\u0101noa\u2019s goal of <a href=\"https:\/\/manoa.hawaii.edu\/wp\/wp-content\/uploads\/2020\/12\/manoa-2025-strategic-plan.pdf#page=25\">Excellence in Research: Advancing the Research and Creative Work Enterprise<\/a> (<span class=\"small-text\"><abbr title=\"Portable Document Format\">PDF<\/abbr><\/span>), one of four goals identified in the <a href=\"https:\/\/manoa.hawaii.edu\/wp\/wp-content\/uploads\/2020\/12\/manoa-2025-strategic-plan.pdf\">2015\u201325 Strategic Plan<\/a> (<span class=\"small-text\"><abbr>PDF<\/abbr><\/span>), updated in December 2020. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cumulina, the first cloned mouse and the first cloned mammal in the United States recently made the trek to her new home in the renowned Smithsonian\u2019s National Museum of American History.<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30,12],"tags":[1040,454,31,1467,158,9,56],"class_list":["post-159530","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","category-video","tag-biomedical-science","tag-institute-for-biogenesis-research","tag-john-a-burns-school-of-medicine","tag-manoa-excellence-in-research","tag-publication","tag-uh-manoa","tag-video-2","entry","has-media"],"aioseo_notices":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/159530","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/comments?post=159530"}],"version-history":[{"count":21,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/159530\/revisions"}],"predecessor-version":[{"id":159824,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/159530\/revisions\/159824"}],"wp:attachment":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/media?parent=159530"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/categories?post=159530"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/tags?post=159530"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}