{"id":121618,"date":"2020-06-26T15:31:34","date_gmt":"2020-06-27T01:31:34","guid":{"rendered":"https:\/\/www.hawaii.edu\/news\/?p=121618"},"modified":"2021-04-21T13:29:54","modified_gmt":"2021-04-21T23:29:54","slug":"change-seq-target-gene-editing","status":"publish","type":"post","link":"https:\/\/www.hawaii.edu\/news\/2020\/06\/26\/change-seq-target-gene-editing\/","title":{"rendered":"Genome editing for children\u2019s diseases could boost agricultural production"},"content":{"rendered":"<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Reading time: <\/span> <span class=\"rt-time\"> &lt; 1<\/span> <span class=\"rt-label rt-postfix\">minute<\/span><\/span><figure id=\"attachment_121596\" aria-describedby=\"caption-attachment-121596\" style=\"width: 676px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2020\/06\/manoa-ctahr-yanghua-he.jpg\" alt=\"Yanghua He holding syringe\" width=\"676\" height=\"381\" class=\"size-full wp-image-121596\" srcset=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2020\/06\/manoa-ctahr-yanghua-he.jpg 676w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2020\/06\/manoa-ctahr-yanghua-he-300x169.jpg 300w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2020\/06\/manoa-ctahr-yanghua-he-130x73.jpg 130w\" sizes=\"auto, (max-width: 676px) 100vw, 676px\" \/><figcaption id=\"caption-attachment-121596\" class=\"wp-caption-text\">Yanghua He<\/figcaption><\/figure>\n<p>A recent study from <abbr title=\"Saint\">St.<\/abbr> Jude Children\u2019s Research Hospital describes a new method for genome editing that could lead to safer, more targeted strategies for treating and potentially curing life-threatening diseases, such as some cancers and blood diseases&#8212;with less risk of unwanted mutations.<\/p>\n<p><abbr>CHANGE-seq<\/abbr>, or &ldquo;circularization for high-throughput analysis of nuclease genome-wide effects by sequencing,&rdquo; is a new method for identifying regions in the genome where a gene-editing process, such as <abbr title=\"clusters of regularly interspaced short palindromic repeats\">CRISPR<\/abbr>-Cas9, is more likely to misidentify the intended target site.<\/p>\n<p>The research team included <strong>Yanghua He<\/strong>, who recently joined the University of <span aria-label=\"Hawaii\">Hawai&#699;i<\/span> at M\u0101noa\u2019s College of Tropical Agriculture and Human Resources (<abbr>CTAHR<\/abbr>) <a href=\"https:\/\/cms.ctahr.hawaii.edu\/hnfas\/\">Department of Human Nutrition, Food and Animal Sciences<\/a> from <abbr title=\"Saint\">St.<\/abbr> Jude, and her colleagues.<\/p>\n<ul>\n<li>Read the full study in <em>Nature<\/em>, &ldquo;<a href=\"https:\/\/www.nature.com\/articles\/s41587-020-0555-7\">CHANGE-seq reveals genetic and epigenetic effects on <abbr>CRISPR<\/abbr>-Cas9 genome-wide activity<\/a>.&rdquo;<\/li>\n<\/ul>\n<p>This method can help researchers figure out whether sites are &ldquo;on target&rdquo;&#8212;the appropriate ones to be edited&#8212;or &ldquo;off target&rdquo;&#8212;such that editing them could lead to accidental mutations.<\/p>\n<p><abbr>CHANGE-seq<\/abbr> could also be used to modify characteristics in plant and animal species to possibly create an improved yield, greater nutritional value or increased tolerance to environmental stresses.<\/p>\n<p>&ldquo;I envision a benefit to agricultural development in <span aria-label=\"Hawaii\">Hawai&#699;i<\/span> through better methods for interpreting and predicting the unintended effects of gene editing,&rdquo; said He. &ldquo;I hope this will inspire confidence in the safety of the next generation of promising genome-editing applications.&rdquo;<\/p>\n<p><a href=\"https:\/\/cms.ctahr.hawaii.edu\/NewsLetter\/on-target-genome-editing\">For more details, visit <abbr>CTAHR<\/abbr>\u2019s website.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p><abbr title=\"College of Tropical Agriculture and Human Resources\">CTAHR<\/abbr>\u2019s Yanghua He and her colleagues developed a new method to accurately identify target sites for genetic modifications.<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[222,212,1485,1363,9],"class_list":["post-121618","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-agriculture","tag-college-of-tropical-agriculture-and-human-resilience","tag-human-nutrition-food-and-animal-sciences","tag-manoa-research","tag-uh-manoa","entry","has-media"],"aioseo_notices":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/121618","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/comments?post=121618"}],"version-history":[{"count":6,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/121618\/revisions"}],"predecessor-version":[{"id":121640,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/121618\/revisions\/121640"}],"wp:attachment":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/media?parent=121618"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/categories?post=121618"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/tags?post=121618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}