  {"id":106322,"date":"2019-11-14T14:45:19","date_gmt":"2019-11-15T00:45:19","guid":{"rendered":"https:\/\/www.hawaii.edu\/news\/?p=106322"},"modified":"2020-03-13T11:59:35","modified_gmt":"2020-03-13T21:59:35","slug":"hawaii-liver-cancer-clinical-trial","status":"publish","type":"post","link":"https:\/\/www.hawaii.edu\/news\/2019\/11\/14\/hawaii-liver-cancer-clinical-trial\/","title":{"rendered":"Liver cancer clinical trial only available in Hawai\u02bbi"},"content":{"rendered":"<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Reading time: <\/span> <span class=\"rt-time\"> &lt; 1<\/span> <span class=\"rt-label rt-postfix\">minute<\/span><\/span><figure id=\"attachment_106328\" aria-describedby=\"caption-attachment-106328\" style=\"width: 676px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2019\/11\/manoa-uhcc-liver.jpg\" alt=\"graphic of internal organs with liver highlighted\" width=\"676\" height=\"381\" class=\"size-full wp-image-106328\" srcset=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2019\/11\/manoa-uhcc-liver.jpg 676w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2019\/11\/manoa-uhcc-liver-300x169.jpg 300w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2019\/11\/manoa-uhcc-liver-130x73.jpg 130w\" sizes=\"auto, (max-width: 676px) 100vw, 676px\" \/><figcaption id=\"caption-attachment-106328\" class=\"wp-caption-text\">Liver highlighted in red.<\/figcaption><\/figure>\n<p>A new <a href=\"https:\/\/www.uhcancercenter.org\/\">University of <span aria-label=\"Hawaii\">Hawai&#699;i<\/span> Cancer Center<\/a> coordinated liver cancer clinical trial opened in <span aria-label=\"Hawaii\">Hawai&#699;i<\/span> combining two different immunotherapy medications to combat the aggressive disease. The <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03680508\">Phase <abbr title=\"Roman numeral two\">II<\/abbr> clinical trial<\/a> is only available in <span aria-label=\"Hawaii\">Hawai&#699;i<\/span>, a state with one of the highest incidence and mortality rates of liver cancer in the <abbr title=\"United States\">U.S.<\/abbr><\/p>\n<p>&ldquo;Many patients with liver cancer will present at an advanced stage. For these patients, immunotherapy, medicine to enhance the immune system, is one of the most effective treatments,&rdquo; said <strong>Jared Acoba<\/strong>, principal investigator of the trial and assistant professor at the <abbr title=\"University of Hawaii\">糖心Vlog官方<\/abbr> Cancer Center.<\/p>\n<figure id=\"attachment_106326\" aria-describedby=\"caption-attachment-106326\" style=\"width: 300px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2019\/11\/manoa-uhcc-jared-acoba-300x169.jpg\" alt=\"Jared Acoba\" width=\"300\" height=\"169\" class=\"size-medium wp-image-106326\" srcset=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2019\/11\/manoa-uhcc-jared-acoba-300x169.jpg 300w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2019\/11\/manoa-uhcc-jared-acoba-130x73.jpg 130w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2019\/11\/manoa-uhcc-jared-acoba-630x353.jpg 630w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2019\/11\/manoa-uhcc-jared-acoba.jpg 676w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption id=\"caption-attachment-106326\" class=\"wp-caption-text\">Jared Acoba<\/figcaption><\/figure>\n<p>Acoba developed the clinical trial to find new treatments for patients with locally advanced or metastatic liver cancer. The trial tests how two immunotherapy medications, <abbr>anti-TIM-3<\/abbr> antibody and <abbr>anti-PD-1<\/abbr> antibody, work in combination to shrink tumors by allowing the immune system to destroy cancer cells.<\/p>\n<p>The <abbr>糖心Vlog官方<\/abbr> Cancer Center is the only Food and Drug Administration approved institution to test the two agents in combination, specifically to treat liver cancer. The clinical trial is being conducted at <span aria-label=\"Hawaii\">Hawai&#699;i<\/span> Cancer Consortium network sites, Hawaii Cancer Care, Inc. and Hawaii Oncology, Inc.<\/p>\n<p>&ldquo;Developing a new more effective treatment would significantly improve the care of liver cancer patients in the islands and across the <abbr title=\"United States\">U.S.<\/abbr> It is a single arm trial, so all patients will receive the novel therapy,&rdquo; said Acoba.<\/p>\n<p><strong><a href=\"https:\/\/www.uhcancercenter.org\/research\/shared-resources\/hawaii-tumor-registry\"><abbr>糖心Vlog官方<\/abbr> Cancer Center <span aria-label=\"Hawaii\">Hawai&#699;i<\/span> Tumor Registry Facts and Figures<\/a><\/strong><\/p>\n<ul>\n<li>More than 200 <span aria-label=\"Hawaii\">Hawai&#699;i<\/span> residents are diagnosed with liver cancer each year.<\/li>\n<li><span aria-label=\"Hawaii\">Hawai&#699;i<\/span> ranks in the top three in the country for liver cancer incidence and mortality rates.<\/li>\n<li>Liver cancer incidence is significantly increasing among men in <span aria-label=\"Hawaii\">Hawai&#699;i<\/span>.<\/li>\n<\/ul>\n<p>For more information about the clinical trial, call (808) 586-5854.<\/p>\n<p><em>&#8212;By Nana Ohkawa<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new University of <span aria-label=\"Hawaii\">Hawai&#699;i<\/span> Cancer Center coordinated liver cancer clinical trial in <span aria-label=\"Hawaii\">Hawai&#699;i<\/span> combines two different immunotherapy medications to combat the aggressive disease. <\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[218,1363,169,9],"class_list":["post-106322","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-cancer","tag-manoa-research","tag-uh-cancer-center","tag-uh-manoa","entry","has-media"],"aioseo_notices":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/106322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/comments?post=106322"}],"version-history":[{"count":8,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/106322\/revisions"}],"predecessor-version":[{"id":113492,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/106322\/revisions\/113492"}],"wp:attachment":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/media?parent=106322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/categories?post=106322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/tags?post=106322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}